氯氮平所致白细胞异常处理措施的研究进展Research progress of the treatment measures about Clozapine-induced leukocyte abnormalities
张俊;庞波;崔明;宋红梅;吴延海;迟正锁;王皖生;
摘要(Abstract):
氯氮平是目前基层医院和社区使用频率较高的抗精神病药,是治疗难治性精神分裂症的一线用药。氯氮平会引起白细胞减少或增多、粒细胞缺乏等问题。本文简要综述氯氮平所致白细胞异常处理措施,为安全合理应用氯氮平提供参考。
关键词(KeyWords): 氯氮平;副作用;白细胞减少;粒细胞减少
基金项目(Foundation):
作者(Author): 张俊;庞波;崔明;宋红梅;吴延海;迟正锁;王皖生;
Email:
DOI:
参考文献(References):
- [1]Lundblad W,Azzam PN,Gopalan P,et al.Medical Management of Patients on Clozapine:A Guide for Internists[J].J Hosp Med,2015,10(8):537-543.
- [2]徐优明,张丽英,王美霞.社区贫困精神分裂症患者免费用药情况调查[J].中国民康医学,2014,26(14):92.
- [3]马继东,潘赞.氯氮平和阿立哌唑单用或联用治疗难治性精神分裂症的疗效及安全性[J].齐齐哈尔医学院学报,2016,37(2):181-182.
- [4]Sriretnakumar V,Huang E,Müller DJ.Pharmacogenetics of clozapine treatment response and side-effects in schizophrenia:an update[J].Expert Opin Drug Metab Toxicol,2015,11(11):1709-1731.
- [5]蒲玉春,阮淑芳.抗精神分裂药致白细胞减少的调查分析[J].深圳中西医结合杂志,2016,26(12):67-69.
- [6]Hayes RD,Downs J,Chang CK,et al.The effect of clozapine on premature mortality:an assessment of clinical monitoring and other potential confounders[J].Schizophr Bull,2015,41(3):644-655.
- [7]卢伟,刘桂霞,成孝军,等.436例氯氮平治疗精神分裂症对白细胞影响的临床分析[J].中国医药导报,2010,7(11):63-64.
- [8]Lau KL,Yim PH.Neutropenia and Agranulocytosis in Chinese Patients Prescribed Clozapine[J].East Asian Arch Psychiatry,2015,25(4):164-167.
- [9]Tamayo Martínez N,Bohórquez Pe1aranda AP,García Valencia J,et al.Hematological Evaluation and Monitoring in Adult Patients Diagnosed With Schizophrenia[J].Rev Colomb Psiquiatr,2015,44(3):131-136.
- [10]Cohen D,Monden M.White blood cell monitoring during longterm clozapine treatment[J].Am J Psychiatry,2013,170(4):366-389.
- [11]Demler TL,Morabito NE,Meyer CE,et al.Maximizing clozapine utilization while minimizing blood dyscrasias:evaluation of patient demographics and severity of events[J].Int Clin Psychopharmacol,2016,31(2):76-83.
- [12]周旭青.社区免费服用氯氮平精神病患者检测血常规顺从情况的分析[J].中国医药指南,2016,14(2):138-139.
- [13]张心保.长期服氯氮平复查血白细胞分类的负担[J].临床精神医学杂志,2014,24(4):288.
- [14]Bogers JP,Bui H,Herruer M,et al.Capillary compared to venous blood sampling in clozapine treatment:patients'and healthcare practitioners'experiences with a point-of-care device[J].Eur Neuropsychopharmacol,2015,25(3):319-324.
- [15]何莉梅,杨智,张海霞,等.22例儿童氯氮平急性中毒临床分析[J].中国药物警戒,2015,12(9):564-566.
- [16]张燕,许海燕,黄文燕,等.氯氮平致粒细胞缺乏的护理体会[J].中国民康医学,2011,23(20):2565.
- [17]Shuman MD,Trigoboff E,Demler TL,et al.Exploring the potential effect of polypharmacy on the hematologic profiles of clozapine patients[J].J Psychiatr Pract,2014,20(1):50-58.
- [18]Tourian L,Margolese HC.Late-onset agranulocytosis in a patient treated with clozapine and lamotrigine[J].J Clin Psychopharmacol,2011,31(5):665-667.
- [19]Bavle A,Vidhyavathi M.Case report of clozapine-induced neutropenia and rechallenge[J].J Neuropsychiatry Clin Neurosci,2015,27(1):61.
- [20]Chowdhury NI,Remington G,Kennedy JL.Genetics of antipsychotic-induced side effects and agranulocytosis[J].Curr Psychiatry Rep,2011,13(2):156-165.
- [21]Aydin M,Ilhan BC,Calisir S,et al.Continuing clozapine treatment with lithium in schizophrenic patients with neutropenia or leukopenia:brief review of literature with case reports[J].Ther Adv Psychopharmacol,2016,6(1):33-38.
- [22]Nooijen PM,Carvalho F,Flanagan RJ.Haematological toxicity of clozapine and some other drugs used in psychiatry[J].Hum Psychopharmacol,2011,26(2):112-119.
- [23]Dumas R,Bardin P,Vedie C.Long-Term Treatment of Clozapine-Induced Leukopenia With Lithium:Fast-Onset Agranulocytosis Following Lithium Discontinuation[J].Prim Care Companion CNS Disord,2016,18(1):doi:10.4088/PCC.15l01841.
- [24]胡亚兰.咖啡酸片治疗氯氮平所致白细胞减少的临床观察[J].四川精神卫生,2012,25(4):207.
- [25]付晓阳,廖彩霞.益血生胶囊对氯氮平所致白细胞减少的疗效观察[J].江西医药,2011,46(4):361-362.
- [26]张智勇,谢玲银,黄伟波,等.奥氮平与氯氮平治疗精神分裂症的疗效与安全性研究[J].中国医学创新,2015,12(32):36-39.
- [27]Manu P,Sarpal D,Muir O,et al.When can patients with potentially life-threatening adverse effects be rechallenged with clozapine?A systematic review of the published literature[J].Schizophr Res,2012,134(2-3):180-186.
- [28]Pushpakumara J,Karunarathna P,Sivathiran S,et al.Clozapine induced pancytopenia leading to severe sepsis:an unusual early complication[J].BMC Res Notes,2015,8(1):792.
- [29]钱东丽,杨广声,王金宝.122例氯氮平所致类感染综合征相关因素分析[J].中国医院用药评价与分析,2004,4(1):45-47.
- [30]Tungaraza TE,Farooq S.Clozapine prescribing in the UK:views and experience of consultant psychiatrists[J].Ther Adv Psychopharmacol,2015,5(2):88-96.