魏德华;陈世玖;

• 1:遵义医科大学第五附属(珠海)医院整形手外科

摘要(Abstract)：

糖尿病溃疡是糖尿病的严重并发症,好发于足部,创面极易迁延不愈,大大提高患者截肢和死亡的风险。糖尿病溃疡的治疗包括对患者的基础管理、清创治疗及辅助治疗等,随着创面治疗技术的发展,近年来临床出现了许多新的辅助治疗方法,如新型敷料、生长因子、负压封闭引流技术、烧伤皮肤再生医疗技术、高压氧治疗等。该文就近年来应用于临床的糖尿病溃疡创面的辅助治疗的研究进展展开综述。

关键词(KeyWords)： 糖尿病溃疡;糖尿病足;清创治疗;辅助治疗;研究进展;综述

Abstract:

Keywords:

基金项目(Foundation): 中国红十字基金会徐荣祥再生生命公益基金（2019第292号）

作者(Author): 魏德华;陈世玖;

Email:

DOI:

参考文献(References)：

• [1]中华医学会糖尿病学分会，中华医学会感染病学分会，中华医学会组织修复与再生分会.中国糖尿病足防治指南（2019版）（Ⅰ）[J].中华糖尿病杂志，2019,11(2):92-108.
• [2] Everett E,Mathioudakis N. Update on management of diabetic foot ulcers[J]. Ann NY Acad Sci,2018,1411(1):153-165.
• [3] Vas P,Rayman G,Dhatariya K,et al. Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes:a systematic review[J]. Diabetes Metab Res Rev,2020,36(s1):e3284.
• [4] Zubir MZM,Holloway S,Noor NM. Maggot therapy in wound healing:A systematic review[J]. Int J Environ Res Public Health.2020,17(17):6103.
• [5] Salehi SH,Momeni M,Vahdani M,et al. Clinical value of debriding enzymes as an adjunct to standard early surgical excision in human burns:A systematic review[J]. J Burn Care Res. 2020,41(6):1224-1230.
• [6]林双，袁丽，杨小玲，等.超声水刀联合负压滴灌治疗在慢性难愈性糖尿病足中的应用效果[J].四川医学，2019,40(7):718-722.
• [7] Aderibigbe BA,Buyana B. Alginate in wound dressings[J].Pharmaceutics,2018,10(2):42.
• [8] Zhang L,Yin H,Lei X,et al. A systematic review and metaanalysis of clinical effectiveness and safety of hydrogel dressings in the management of skin wounds[J]. Front Bioeng Biotechnol,2019,(7):342.
• [9] Kong D,Zhang Q,You J,et al. Adhesion loss mechanism based on carboxymethyl cellulose-filled hydrocolloid dressings in physiological wounds environment[J]. Carbohydr Polym,2020,(235):115953.
• [10] Lithner F. Adverse effects on diabetic foot ulcers of highly adhesive hydrocolloid occlusive dressing[J]. Diabetes Care,1990,13(7):814-815.
• [11] Davies P,McCarty S,Hamberg K. Silver-containing foam dressings with Safetac:a review of the scientific and clinical data[J]. J Wound Care,2017,26(6):1-32.
• [12] Shi R,Lian W,Han S,et al. Nanosphere-mediated co-delivery of VEGF-A and PDGF-B genes for accelerating diabetic foot ulcers healing in rats[J]. Gene Ther,2018,25(6):425-438.
• [13] Sridharan K,Sivaramakrishnan G. Growth factors for diabetic foot ulcers:mixed treatment comparison analysis of randomized clinical trials[J]. Br J Clin Pharmacol,2018,84(3):434-444.
• [14] Ahmed M,Reffat SA,Hassan A,et al. Platelet-rich plasma for the treatment of clean diabetic foot ulcers[J]. Ann Vasc Surg,2017,(38):206-211.
• [15] Romero PM,Roa C,Alfonso P,et al. Cost-effectiveness analysis of the human recombinant epidermal growth factor in the management of patients with diabetic foot ulcers[J]. Diabet Foot Ankle,2018,9(1):1480249.
• [16] Rys P,Borys S,Hohendorff J,et al. NPWT in diabetic foot wounds-a systematic review and meta-analysis of observational studies[J]. Endocrine,2020,68(1):44-55.
• [17]王洪生.皮肤原位再生医疗技术治疗糖尿病足溃疡的临床诊治规范[J].中国烧伤创疡杂志，2016,28(3):155-191.
• [18]何坤，甘仲霖，杨艳，等.湿润烧伤膏治疗糖尿病足溃疡疗效的系统评价[J].西南医科大学学报，2017,40(3):243-248.
• [19]刘明，唐乾利，李杰辉，等.烧伤湿润暴露疗法及湿润烧伤膏治疗糖尿病足的效果及对创面组织血管内皮生长因子和表皮细胞生长因子水平的影响[J].广西医学，2018,40(11):1157-1160.
• [20] Kumar A, Shukla U,Prabhakar T,et al. Hyperbaric oxygen therapy as an adjuvant to standard therapy in the treatment of diabetic foot ulcers[J]. J Anaesthesiol Clin Pharmacol,2020,36(2):213-218.
• [21] Huang X,Liang P,Jiang B,et al. Hyperbaric oxygen potentiates diabetic wound healing by promoting fibroblast cell proliferation and endothelial cell angiogenesis[J]. Life Sci,2020,(259):118246.
• [22] Chen W,Liang X,Nong Z,et al. The multiple applications and possible mechanisms of the hyperbaric oxygenation therapy[J]. Med Chem,2019,15(5):459-471.
• [23] Chou PR,Lin YN,Wu SH,et al. Supercritical carbon dioxidedecellularized porcine acellular dermal matrix combined with autologous adipose-derived stem cells:its role in accelerated diabetic wound healing[J]. Int J Med Sci,2020,17(3):354-367.
• [24] Garwood CS,Steinberg JS,Kim PJ. Bioengineered alternative tissues in diabetic wound healing[J]. Clin Podiatr Med Surg,2015,32(1):121-133.
• [25]álvaro-Afonso FJ,Sanz-Corbalán I,Lázaro-Martínez JL,et al. Adipose-derived mesenchymal stem cells in the treatment of diabetic foot ulcers:A review of preclinical and clinical studies[J].Angiology,2020,71(9):853-863.
• [26]邓书华，丁胜兰，Lurant，等.蜂蜜敷料治疗糖尿病足溃疡疗效和安全性：Meta分析[J].中华糖尿病杂志，2019,11(7):482-488.
• [27]孟昕珂.稳恒磁场在糖尿病足溃疡创面愈合中的应用研究进展[J].吉林医学，2018,39(10):1975-1977.