小剂量奥氮平作为增效剂辅助治疗31例难治性强迫症的对照研究Small Olanzpine as an adjunctive treatment for refractory Obsessive - compulsive disorder
文万军;陈晔;张程赪;魏炎;覃宗厚;
摘要(Abstract):
目的:探讨小剂量奥氮平作为增效剂治疗难治性强迫症的疗效和耐受性。方法:选取59例难治性强迫症患者为研究对象,对31例难治性强迫症患者在原SSRI类药物治疗的基础上联合奥氮平治疗,同时以28例继续应用SSRI类药物治疗的难治性强迫症患者为对照。奥氮平起始量为第1周5mg/d,第2周为10mg/d,第3周为15mg/d口服,之后可根据个体的疗效和耐受情况调整剂量,最大剂量不超过20mg/d,疗程8周;采用Yale-Brown强迫量表,汉密尔顿焦虑量表,总体评定量表及副反应评定量表分别在治疗前,治疗第4周末及治疗第8周末各评定1次,并进行对比分析。结果:治疗第8周末,研究组Yale-Brown强迫量表(12.0±5.4)分,汉密尔顿焦虑量表(13.7±3.2)分、大体评定量表总分(48.2±11.7)分与治疗前分别为(29.8±5.4)分,(23.50±3.61)分,(26.95±10,61)分,治疗前后比较差异均有显著性(P<0.01);Yale-Brown强迫量表减分率判定:痊愈率16%,有效率48%,无效36%;不良反应程度较轻微,患者均可耐受并与对照组在各项量表评分上差异具有显著性。结论:小剂量奥氮平可作为常规抗抑郁剂的增效剂治疗难治性强迫症,疗效较好。
关键词(KeyWords): 奥氮平;增效剂;难治性强迫症
基金项目(Foundation):
作者(Author): 文万军;陈晔;张程赪;魏炎;覃宗厚;
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参考文献(References):
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